Seniors Chelsea Brown and Tristan Morris, along with sophomore Ella Carter, will compete against Rocky Mount and Southern Lee. The game show will air on WRAL at 11 a.m.
The Brain Game tests high school teams from the WRAL viewing area in categories like Pop Culture, Headliners, Science, Math, and Literature and Arts.
The show is hosted by WRAL personality Mark Roberts.
Thirty-six schools began the competition in November. It ends in a championship game in April.