Cobler Drive is located outside Roanoke Rapids off Three Bridges Road.
Chief Deputy Scott Hall said in a statement the plants were found after Lieutenant J. Bozard, Sergeant R. Ball and Detective M. Brown were following up on a drug complaint.
Investigation led to the execution of a search warrant on the residence.
The deputies seized a total of five marijuana plants, numerous items of marijuana paraphernalia, and personal use marijuana.
A total of 392 grams of marijuana was seized. Hall said the 392 grams account for the plants seized as well as marijuana found inside the residence.
It was not clear how long the plants had been growing or whether the marijuana was being grown for personal use or sale on the street.
Brown arrested and charged David Allen Medlin and Mark Thomas Walker, both 55, with felony possession of marijuana, possession with intent to manufacture, sell, and deliver marijuana, maintaining a dwelling place to keep a controlled substance, manufacture marijuana, simple possession of marijuana and possession of marijuana paraphernalia.
Both men received $8,000 bonds and August 15 court dates.