Halifax County Sheriff Wes Tripp, who declined comment beyond a statement emailed late Wednesday night, said the two students have been charged with first-degree rape.
Tripp said the alleged rape occurred when 18-year-old Raquan Marquest Boswell and 16-year-old Jesse Jyrell Alston pushed and restrained a female student in a male locker room area.
Working with school resource officers, Sergeant Lindsay Mann charged the students, Boswell, of Roanoke Rapids, and Alston, of Littleton.
They have November 15 court dates.
Investigation continues and more arrests are possible.
Other HCSO reports
On July 17 deputies responded to a breaking and entering report at a residence on Bowers Road in the area of Littleton.
Through further investigation by Detective R.B. Biggerstaff, warrants were obtained on Glenn Junior Hubbard, 65, of Rocky Mount.
Hubbard was charged with breaking and entering, larceny after breaking and entering, possession of stolen goods and injury to real property.
He was arrested Wednesday and has a first court appearance October 4.
On September 12 deputies responded to a residence on Highway 48 in the Roanoke Rapids area on a call of larceny of a firearm and other items.
Biggerstaff obtained warrants on Lisa Faye Davis, 52, of Gaston.
Davis was charged with larceny of a firearm, possession of a stolen firearm, larceny, possession of stolen goods and obtaining property by false pretense.
The obtaining property charge stemmed from Davis selling stolen property to a pawn shop in the Roanoke Rapids area.
She was arrested Wednesday and has an October 11 court date.